Periodontitis Increases Risk of Bacteria in Donated Blood

Dentistry Today


There is an increased risk of bacterial contamination in donated blood if the donor suffers from periodontitis, according to researchers at the University of Copenhagen, who emphasize that blood transfusions are still safe. However, the researchers add, their findings indicate that the screening approach should be reviewed.

Blood donors donate approximately 120 million portions of blood around the world each year, the researchers said. These donations save lives, but in rare cases, the researchers added, the transfusion itself can be the cause of an infection. In Denmark, all donor blood is screened for hepatitis and HIV to reduce the risk of transfusion-transmitted infection.

In their study, the researchers found that the risk of bacterial contamination increases if donors have periodontitis. The results also indicate that bacteria originating from the oral cavity evades the routine screenings that are generally used.

Approximately half of the adult population above the age of 50 in the industrialized world has periodontitis, the researchers said. Also, a growing number of studies have linked periodontitis to diseases outside the oral cavity including diabetes, cardiovascular disease, and rheumatoid arthritis.

“Our results show a 6.4 times higher prevalence of viable bacteria in the blood donated by donors suffering from periodontitis compared to donors not suffering from periodontitis,” said associate professor Christian Damgaard, PhD, of the Department of Odontology in the Faculty of Health and Medical Sciences at the University of Copenhagen.

“That is a highly significant difference. It is noteworthy that the bacteria are not detected by the screening system currently used in the blood bank,” Damgaard said.

“The presence of periodontitis implies having a large infected wound from which bacteria can enter the circulation. Every time you brush your teeth or chew food, the periodontal bacteria have direct access to the circulation,” said Damgaard.

The researchers tested donor blood samples via different methods. They used the exact same method as blood banks using oxygen-rich incubation. They also have isolated the red blood cells and investigated growth using oxygen-free conditions. Using this approach, the researchers made an important observation, Damgaard said.

“None of the samples studied by the usual screening method showed bacterial contamination. Thus, these products would have been approved for transfusion. On the contrary, when we studied the same samples using our more advanced method, we actually found viable bacteria in the blood,” Damgaard said.

The risk of developing periodontitis increases with increasing age. Therefore, the researchers sampled blood from 60 different donors all above the age of 50. Approximately half of the donors turned out to have periodontitis.

With this study, the researchers shed light on one aspect of the quality and control of donor blood, which may affect the risk of infections requiring hospital treatment. However, the researchers stressed that they do not know whether the observed bacterial growth has any clinical impact.

Experience shows that receiving donor blood is generally safe, said Susanne Gjørup Sækmose, consultant doctor at the Department of Clinical Immunology, Region Zealand.

“Patients can safely receive blood transfusion. In Denmark, we conduct around 360,000 blood transfusions a year, and infections due to blood transfusions are extremely rare, with less than one per year on average. In addition, we have a national system for monitoring side effects,” Gjørup Sækmose said.

The low incidence of infections caused by blood transfusions may be a result of the high level of safety, the researchers said. Also, the immune system will protect the patient from bacteria in the transfused blood. However, the researchers added, not all infections are reported to the blood bank.

Therefore, the researchers said, it is important to identify risk factors that can lead to bacterial contamination, such as periodontitis, especially because donors do not necessarily consider periodontitis a factor worth mentioning when interviewed.

“In our experience, blood donors make sure to mention any diseases that may affect the quality of the blood. But few consider periodontitis a relevant disease. Therefore, most donors probably do not mention it to the blood bank,” said Gjørup Sækmose.

“Our study suggests that we may have to develop new methods for efficient screening of donor blood in the future. But really, the most important point is to make sure that everyone sees the mouth as a part of our organism. Basically, diseases in the mouth may affect our overall state of health,” said Gjørup Sækmose.

The study, “Periodontitis Increases Risk of Viable Bacteria in Freshly Drawn Blood Donations,” was published by Blood Transfusion.

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