The European League Against Rheumatism (EULAR) has published recommendations for the management of patients with Sjögren’s syndrome (SjS) with topical and systemic therapies.
The therapeutic management of SjS has not changed substantially in recent decades, EULAR says, as treatment decisions remain challenging in clinical practice without a specific therapeutic target beyond relief of symptoms as the most important goal.
With this in mind, EULAR supported an international task force to develop evidence-based and consensus-based recommendations for the management of SjS patients with topical and systemic medications.
The task force developed three overarching principles and 12 specific recommendations for SjS management. These recommendations form a logical sequence starting with the management of the central triplet of symptoms—dryness, fatigue, and pain—followed by the management of systemic disease.
The three overarching principles are:
- Patients with SjS should be managed at or in close collaboration with centers of expertise using a multidisciplinary approach.
- The first therapeutic approach to dryness should be symptomatic relief using topical therapies.
- Systemic therapies may be considered for the treatment of active systemic disease.
The 12 specific recommendations are:
- Baseline evaluation of salivary gland function is recommended before starting treatment for oral dryness.
- The preferred first therapeutic approach for oral dryness according to salivary gland function may be non-pharmacological stimulation for mild dysfunction, pharmacological stimulation for moderate dysfunction, or saliva substitution for severe dysfunction.
- The first-line therapeutic approach to ocular dryness includes artificial tears and ocular gels and ointments.
- Refractory/severe ocular dryness may be managed using topical immunosuppressive-containing drops and serum eyedrops.
- Concomitant diseases should be evaluated in patients presenting with fatigue or pain whose severity should be scored using specific tools.
- Consider analgesics or other pain-modifying agents for musculoskeletal pain, accounting for the balance between potential benefits and side effects.
- Treatment of systemic disease should be tailored to organ-specific severity using the EULAR SjS disease activity index ESSDAI definitions.
- Glucocorticoids (GCs) should be used at the minimum dose and length of time necessary to control active systemic disease.
- Synthetic immunosuppressive agents should mainly be used as GC-sparing agents, with no evidence supporting the choice of one agent over another.
- B-cell targeted therapies may be considered in patients with severe, refractory systemic disease.
- The systemic organ-specific therapeutic approach may, as a general rule, follow the sequential (or combined) use of GCs, immunosuppressive agents, and biologics.
- Treatment of B-cell lymphoma should be individualized according to the specific histological subtype and disease stage.