Women with obstructive sleep apnea (OSA) appear to be at an elevated risk of getting cancer, report researchers at the University of Gothenburg. No causal relationship is demonstrated, but the link between nocturnal hypoxia in women and higher cancer risk is still clear.
“It’s reasonable to assume that sleep apnea is a risk factor for cancer or that both conditions have common risk factors, such as overweight. On the other hand, it is less likely that cancer leads to sleep apnea,” said Ludger Grote, MD, PhD, adjunct professor in pulmonary medicine and chief physician in sleep medicine at Sahlgrenska Academy at the university.
The research is based on analyses of registry data collected in the European EDADA database on 20,000 adult patients with OSA. About 2% of these subjects also had a cancer diagnosis.
As expected, advanced age was associated with elevated cancer risk. But after adjusting the data for age, gender, body mass index, smoking, and alcohol consumption, the researchers also found a possible link between intermittent hypoxia at night and higher cancer prevalence. The connection applied mainly to women and was weaker in men.
“Our results indicate a cancer risk that’s elevated two- to threefold among women with pronounced sleep apnea. It’s impossible to say for sure what causes underlie the association between sleep apnea and cancer, but the indication means we need to study it in more depth,” said Grote, who also is the head of medicine at the Department of Sleep Medicine at Sahlgrenska University Hospital.
“The condition of sleep apnea is well known to the general public and associated with snoring, daytime fatigue, and elevated risk of cardiovascular disease, especially in men. Our research paves the way for a new view that sleep apnea may possibly be connected with increased cancer risk, especially in women,” said Grote.
Previous studies have shown that, more often than others, people with sleep apnea have a cancer diagnosis in their medical history. Research in this area is expanding, while the gender aspects have hardly been explored, the researchers said.
“Above all, the focus has been on the connection with one form of cancer, malignant melanoma. Cancer of the breast or womb may now become a new area. There may be a combined effect of female sex hormones and stress activation, induced by nocturnal hypoxia in sleep apnea, that can trigger cancer development or a weakening of the body’s immune system,” Grote said.
The study, “Cancer Prevalence Is Increased in Females with Sleep Apnoea: Data from the ESADA Study,” was published by the European Respiratory Journal.