Gingival Stem Cells May be Utilized in Tissue Regeneration

Gingival stem cells may have some newly discovered capabilities.

Gingiva was recently identified to possess mesenchymal stem cells. Essentially, it may be possible for gingiva to spur tissue regeneration. The gingiva represents a unique soft tissue that acts as a biological barrier to protecting the oral cavity side of the maxilla and mandible.

The information comes from a report by the International and American Associations for Dental Research. The report appeared in the Journal of Dental Research.

The research team showed that 90 percent of GMSCs stem from cranial neural crest cells and 10 percent from the mesoderm. When compared to the mesoderm MSCs, the CNCCs demonstrate an increased capacity to distinguish neural cells and chondrocytes. After being transplanted into mice with dextran sulfate sodium-induced colitis, N-GMSCs displayed better effects in ameliorating inflammatory types of disease phenotype when compared with the M-GMSC treatment group.

More research is necessary to fully comprehend the connection between the neural crest cell and mesoderm that come from the gingiva mesenchymal stem cells. But it could be possible for gingiva to lead to stem cell regeneration.



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