Industry News

89% of Adolescents Consume Sports Drinks

89% of Adolescents Consume Sports Drinks

28 June 2017

Sports drinks continue to be popular among adolescents, with 89% of 12- to 14-year-olds consuming...

eBooks

May 2017

The Dentist’s Guide
To Managing Employees

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April 2017

Composite Vs. Porcelain’s:
What You Need To Know

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March 2017

Digital Marketing for Dentists

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February 2017

Traumatic Dental Injuries: Emergency Assessment And Treatment

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Recent Issues

June 2017

Digital Technologies: Changing the Face of Dentistry




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May 2017

Solving Aesthetic Challenges From Trauma-Based Injuries




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Researchers Make Possible Breakthrough in Oral Cancer Research

There may be a new, more definitive reason for why people develop oral or esophageal cancer.

New research developed by the University of Pennsylvania School of Medicine shows that a protein that enables cells to stick together is often not present or out of place when a person has oral or esophageal cancer. It’s not certain at this point, however, that the loss of the protein correlates to the presence of tumors.

Cancer in the oral cavity and esophagus affects more than 650,000 people every year.

The investigators made this finding by creating mice that did not have the protein, p120-catenin, in their oral-upper digestive tract. The results were that these mice developed squamous cell cancers.

This study, which was published in the journal Cancer Cell, gives credence to the idea that p120-ctn is involved with suppressing tumors. The tumors the mouse developed mirrored the tumors that generally develop in humans.

When the tissue is healthy, the p120-ctn is part of a larger group of proteins that enable the cells to maintain their position in tightly packed sheets. If the proteins are not present, the following cancers may develop: prostate, breast, colon, pancreas, bladder, skin and endometrial.

When the previous animals that were created did not have the protein, problems arose because they cannot survive during the embryonic process or directly after birth unless they have the protein. The problem was solved by a process known as Cre-Lox, which enables the animals to be created without a certain gene in only a subset of tissues.

The mice were created without p120-ctn in their oral cavity, esophagus and forestomach. After surviving, the mice showed signs of precancerous lesions after about four to six months. By the time they reached nine to 12 months, 70 percent of the animals developed full-blown tumors. To compare, none of the mice born with the protein showed signs of cancer.

This information could be vital in developing new approaches to tumor treatment in humans.

The Wednesday Watch

Exclusive Interview: Patient Education and GentleWave

Exclusive Interview: Patient Education and GentleWave

21 June 2017

Patients are becoming more educated, as a world of information is readily available at our...

Technique of the Week

e-Prescribing with XLDent

e-Prescribing with XLDent

29 March 2017

Drs. David Andersen and Lora Nelson explain how easy e-Prescribing...

Technology Today

Show Me the Way

Show Me the Way

02 May 2017

This year’s International Dental Show did not disappoint: 155,000 participants from 157 countries attended,...

Implants Today

Dental Implant Prosthetic Options

01 June 2017

While implants have the mechanical availability to attach many different prosthetic options, many factors...

Quick Technique

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