Industry News

89% of Adolescents Consume Sports Drinks

89% of Adolescents Consume Sports Drinks

28 June 2017

Sports drinks continue to be popular among adolescents, with 89% of 12- to 14-year-olds consuming...

eBooks

May 2017

The Dentist’s Guide
To Managing Employees

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April 2017

Composite Vs. Porcelain’s:
What You Need To Know

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March 2017

Digital Marketing for Dentists

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February 2017

Traumatic Dental Injuries: Emergency Assessment And Treatment

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Recent Issues

June 2017

Digital Technologies: Changing the Face of Dentistry




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May 2017

Solving Aesthetic Challenges From Trauma-Based Injuries




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Clinical Trial of Tooth Regeneration

It is well known that oral infection progressively destroys periodontal tissues and is the leading cause of tooth loss in adults. A major goal of periodontal treatment is regeneration of the tissues lost to periodontitis. Unfortunately, most current therapies cannot predictably promote repair of tooth-supporting defects. A variety of regenerative approaches have been used clinically using bone grafts and guiding tissue membranes with limited success.

In a new article published in the International and American Associations for Dental Research’s Journal of Dental Research, M. Kitamura, from Osaka University Graduate School of Dentistry, Japan, and a team of researchers conducted a human clinical trial to determine the safety and effectiveness of fibroblast growth factor-2 (FGF-2) for clinical application. This is the largest study to date in the field of periodontal regenerative therapy.

A randomized, double-masked, placebo-controlled clinical trial was conducted in 253 adults afflicted with periodontitis. Periodontal surgery was performed, during which one of three different doses of FGF-2 was randomly administered to localized bone defects. Each dose of FGF-2 showed significant superiority over the standard of care (vehicle alone (P < .01)) for the percentage of bone fill at 36 weeks after administration, and the percentage peaked in the mid-dose FGF-2 group. These results strongly support the topical application of FGF-2 can be efficacious in the regeneration of human periodontal tissue that has been destroyed by periodontitis.

“This study represents the largest multicenter human clinical trial using growth factor therapy to repair tooth-supporting osseous defects,” said JDR Editor-in-Chief William Giannobile. “The tissue engineering technology has important ramifications in the treating of localized bone defects around teeth resulting from periodontal disease.”

In an accompanying editorial, author Martha Somerman, University of Washington, Seattle, states “for periodontal regeneration to continue as an attractive approach for restoring tissues lost to disease versus the choice for extraction and implant placement, we must focus our efforts on developing predictable therapies that include substantial restoration of tissues to physiological health with positive outcomes over the long term (eg, greater than 10 years), as well as containing costs for our patients.”

 

The Wednesday Watch

Exclusive Interview: Patient Education and GentleWave

Exclusive Interview: Patient Education and GentleWave

21 June 2017

Patients are becoming more educated, as a world of information is readily available at our...

Technique of the Week

e-Prescribing with XLDent

e-Prescribing with XLDent

29 March 2017

Drs. David Andersen and Lora Nelson explain how easy e-Prescribing...

Technology Today

Show Me the Way

Show Me the Way

02 May 2017

This year’s International Dental Show did not disappoint: 155,000 participants from 157 countries attended,...

Implants Today

Dental Implant Prosthetic Options

01 June 2017

While implants have the mechanical availability to attach many different prosthetic options, many factors...

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