Industry News

89% of Adolescents Consume Sports Drinks

89% of Adolescents Consume Sports Drinks

28 June 2017

Sports drinks continue to be popular among adolescents, with 89% of 12- to 14-year-olds consuming...

eBooks

May 2017

The Dentist’s Guide
To Managing Employees

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April 2017

Composite Vs. Porcelain’s:
What You Need To Know

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March 2017

Digital Marketing for Dentists

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February 2017

Traumatic Dental Injuries: Emergency Assessment And Treatment

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Recent Issues

June 2017

Digital Technologies: Changing the Face of Dentistry




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May 2017

Solving Aesthetic Challenges From Trauma-Based Injuries




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Taste Genes Predict Tooth Decay

Dental caries is a highly prevalent disease that is disproportionately distributed in the population. Caries occurrence and progression is known to be influenced by a complex interplay of both environmental and genetic factors, with numerous contributing factors having been identified, including bacterial flora, dietary habits, fluoride exposure, oral hygiene, salivary flow, salivary composition, and tooth structure. Previous reports have characterized the influence of the genetic variation on taste preferences and dietary habits.

In an article published in the Journal of Dental Research titled “Taste Genes Associated with Dental Caries” lead researcher Steven Wendell and researchers Melissa Brown, Margaret Cooper, Rebecca DeSensi, Mary Marazita, Xiaojing Wang and Robert Weyant, all from the University of Pittsburgh; and Richard Crout and Daniel McNeil from West Virginia University, hypothesized that genetic variation in taste pathway genes (TAS2R38, TAS1R2, GNAT3) may be associated with dental caries risk and/or protection.

In this study, families were recruited by the Center for Oral Health Research in Appalachia (COHRA) for collection of biological samples, demographic data and clinical assessment of oral health including caries scores. Multiple single nucleotide polymorphism (SNP) assays for each gene were performed and analyzed using transmission disequilibrium test (TDT) analysis (FBAT software) for three dentition groups: primary, mixed, and permanent. Statistically significant associations were seen in TAS2R38 and TAS1R2 for caries risk and/or protection.

“This work is significant in that it identifies key genes that may explain the susceptibilities of some patients to tooth decay,” said JDR Editor-in-Chief William Giannobile. “Although an early study, this breakthrough on taste pathways and genes demonstrates how patient preferences that are genetically predetermined may put patients at risk for disease.”

 

The Wednesday Watch

Exclusive Interview: Patient Education and GentleWave

Exclusive Interview: Patient Education and GentleWave

21 June 2017

Patients are becoming more educated, as a world of information is readily available at our...

Technique of the Week

e-Prescribing with XLDent

e-Prescribing with XLDent

29 March 2017

Drs. David Andersen and Lora Nelson explain how easy e-Prescribing...

Technology Today

Show Me the Way

Show Me the Way

02 May 2017

This year’s International Dental Show did not disappoint: 155,000 participants from 157 countries attended,...

Implants Today

Dental Implant Prosthetic Options

01 June 2017

While implants have the mechanical availability to attach many different prosthetic options, many factors...

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