Industry News

Manchester Dental Conference to Continue as Scheduled

Manchester Dental Conference to Continue as Scheduled

24 May 2017

The British Dental Association (BDA) has informed its delegates that the British Dental Conference and...

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April 2017

Composite Vs. Porcelain’s:
What You Need To Know

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March 2017

Digital Marketing for Dentists

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February 2017

Traumatic Dental Injuries: Emergency Assessment And Treatment

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January 2017

Buffered Anesthesia: Efficiency & Profitability

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May 2017

Solving Aesthetic Challenges From Trauma-Based Injuries




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April 2017

New Trends in Endodontics and Treatment Planning




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Addition of ATP to Midazolam Offers Enhanced Dental Sedation

The anesthetic drug midazolam is in widespread use for brief dental and medical procedures due to its sedative and amnestic properties. However, cardiorespiratory depression can occur when it is given in higher doses or repeatedly to achieve deeper levels of sedation. A new study tests the ability of an added drug, adenosine 5′-triphosate (ATP), to safely achieve these deeper levels of anesthesia. The current issue of the journal Anesthesia Progress reports results of a study of 10 healthy volunteers who underwent 2 anesthetic experiments at least 2 weeks apart. In one session, the volunteers received intravenous bolus administration of midazolam followed by a continuous infusion of ATP for 40 minutes. In the other session, the patients received a placebo infusion of saline after the midazolam. The patients were monitored for 60 minutes. Changes in systolic blood pressure, heart rate, respiratory rate, and other cardiorespiratory measures were recorded every 5 minutes. Bispectral index (BIS) was used to evaluate the depth of anesthesia the patients experienced. BIS analyzes electroencephalogram (EEG) patterns to continuously assess the depth of sedation. The patients’ consciousness was evaluated by their response to verbal commands such as “squeeze my fingers” and “open your eyes.” These parameters showed a deeper level of sedation for the use of midazolam plus ATP. Under midazolam alone, patients showed a BIS value that went from 97 (± 1) prior to administration to 68 (± 18) after 25 minutes. The volunteers remained conscious, but showed signs of significant cardiopulmonary depressant effects. However, following 15 to 30 minutes of coadministration of ATP, no adverse cardiorespiratory effects were seen and patients became unconscious. The BIS value further reduced to 51 (± 13) after receiving ATP. No adverse effects such as hypotension, chest pains, headache, nausea, or vomiting were seen. The authors conclude that the addition of ATP significantly enhances the sedation effect of midazolam with improved cardiorespiratory functions.


(Source: Sakurai S, et al. IV ATP potentiates midazolam sedation as assessed by bispectral index. Anesthesia Progress. Fall 2014, volume 61, number 3)

The Wednesday Watch

Exclusive Interview: Dr. Thomas McClammy

Exclusive Interview: Dr. Thomas McClammy

24 May 2017

Dr. Tom McClammy speaks to us fresh from the stage after his GentleWave presentation at...

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e-Prescribing with XLDent

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29 March 2017

Drs. David Andersen and Lora Nelson explain how easy e-Prescribing...

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Show Me the Way

Show Me the Way

02 May 2017

This year’s International Dental Show did not disappoint: 155,000 participants from 157 countries attended,...

Implants Today

Narrow-Body  Dental Implants

Narrow-Body Dental Implants

02 May 2017

As the multibillion-dollar market for dental implants grows, many new companies are entering the...

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