The findings may help develop better therapies and prognostics for the disease.
Researchers have traced the molecular interactions that allow a protein to escape the nucleus of a breast cancer cell and extend its life.
The findings may help develop better therapies and prognostics for the disease, researchers say.
If the fight against breast cancer were a criminal investigation, then the proteins surviving, HDAC6, CBP, and CRM1 would be among the chief suspects. A new study published in the Journal of Biological Chemistry reveals the key moment for keeping cancer cells alive is the survivin’s jailbreak from the nucleus, aided and abetted by the other proteins.
The study highlights that a protein’s location in a cell affects its impact on disease and offers clear new leads for the investigation.
All four proteins were already under suspicion. Scientists, for example, have already tried to assess what levels of HDAC6 in patients with estrogen-receptor positive breast cancer may mean for their prognosis, but the results have been inconclusive.