Antimicrobial Photodynamic Therapy for Periodontitis

Investigating changes occurring in the sub­gingival microbiological composition of subjects with aggressive periodontitis who were treated with antimicrobial photodynamic therapy (aPDT) in a single epi­sode, or scaling and root planing (SRP), this study by Dr. Arthur Novaes, et al used a split-mouth design on negative-7, zero, and plus-90 days. Ten patients were randomly as­­signed to either aPDT using a laser source in conjunction with a photosensitizer, or SRP with hand instruments. Sub­gingival plaque samples were collected and using checkerboard DNA-DNA hy­bridization determined counts of 40 subgingival species. The data were analyzed using the method of generalized estimating equations to test the associations be­tween treatments, evaluated parameters, and experimental times (α =  .05). The re­sults indicated that aPDT was more effective in lowering Aggregatibacter actinomy­cetem­co­mitans numbers; SRP was more efficient in reducing the presence of Red Com­plex periodontal pathogens. Within this trial, aPDT and SRP effects on different groups of bacteria suggest that their association may be beneficial for the nonsurgical treatment of aggressive periodontitis.
(Source: Lasers in Medical Science, accessed March 21, 2011)

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