Bisphosphonates and Oral Health

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People undergoing bisphosphonate therapy to prevent or treat osteoporosis (a thinning of the bones) may be unfamiliar with the drug and possible adverse side effects on oral health, according to a study in the Journal of the American Dental Association. Use of bisphosphonates has been associated with a small risk of developing bisphosphonate-associated osteonecrosis of the jaw (BON) that occurs spontane­ously or after the patient has undergone dental surgery. BON is a rare but serious condition that can cause severe damage to the jawbone. The prevalence of BON is between 3% and 12% for patients who receive bisphosphonates intra­venously for cancer therapy and less than 1% for patients who receive bisphosphonates orally for osteoporosis or os­teopenia. The study authors sought to determine whether patients taking bisphosphonates had knowledge about the medical indication for the therapy and how long the treatment would last. They also wanted to know whether participants’ physicians told them about possible adverse reactions. The re­searchers in­terviewed 73 participants (71 women, 2 men) seeking routine care in a dental clinic. These participants, with an average age of 66 years that ranged from 44 to 88 years, also were undergoing bisphosphonate treatment. Of the participants, 84% stated they knew why they were receiving bisphosphonate therapy. However, 80% said they were unsure about the duration of the therapy and 82% could not recall receiving information about the risk of experiencing adverse reactions, in­cluding oral osteonecrosis, by their physicians. 

“The results of our small study show that patients who take bisphosphonates may not be aware that BON can develop after they undergo invasive dental care,” the authors wrote. “We believe that a more effective communication process between prescribing physicians, dentists, and patients using bisphosphonates is needed.” The ADA Advisory Com­mittee on Medication-induced Osteonecrosis of the Jaw recommends that dental patients on bisphosphonate therapy advise their dentists. The Com­mittee believes that it is always appropriate for physicians to encourage patients to visit the dentist regularly for professional cleanings and oral ex­ams, as recommended by their dentist. This is especially im­portant for patients whose oral health is put at risk from medications or medical problems.


 (Source: ADA, May 26, 2010)



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