Discovery of Molecule Regulator in Blood-Pressure Control System

To shed light on what determines the availability of the molecules involved in blood-pressure control, researchers at Oregon Health & Science University (OHSU) School of Dentistry published their findings in the Journal of Neu­roscience Research. They discovered that nitric oxide is a powerful regulator of a molecule that plays a critical role in the development and function of the nervous system. The finding could someday play a significant role in the prevention and treatment of high blood pressure, which affects about one in 3 adults in the United States. Changes in blood pressure are signaled to the brain by nerve cells called baroreceptors. The OHSU dental school team previously found that baroreceptors make a molecule called brain-derived neurotrophic factor (BDNF), which belongs to the family of neurotrophins that play a critical role in the development and plasticity of other nerve cells. The team found that nitric oxide is a potent regulator of BDNF in baroreceptor neurons. Nitric oxide is known for its ability to improve the elasticity of blood vessels and to lower blood pressure. It is the active metabolite of nitroglycerin, which has been used to treat coronary artery disease for more than 100 years. Nitric oxide widens small arteries and counteracts artery stiffening, and several lines of evidence also indicate that its deficiency leads to hypertension. 
“This is the first study to show the role of nitric oxide in inhibiting BDNF release from peripheral nerve cells,” said Agnieszka Balkowiec, MD, PhD, principal investigator, associate professor of integrative biosciences in the OHSU School of Dentistry, and adjunct assistant professor of physiology and pharmacology in the OHSU School of Medicine. “This finding supports our hypothesis that BDNF is involved in establishing connections in the blood pressure control system and could someday play a significant role in the prevention of high blood pressure.” The study was supported by grants from the American Heart As­sociation and the National In­stitutes of Health’s National Heart, Lung, and Blood Insti­tute, including the American Recovery and Reinvestment Act funds.

 (Source: OHSU School of Dentistry news release, March 11, 2010.)