FacebookTwitterDiggGoogle BookmarksRedditLinkedinRSS FeedPinterest
Pin It

Granzyme B and Oral Squamous Cell Carcinoma

Granzyme B (GB) is a serine protease that is synthesized by activated cytotoxic T-lymphocytes and natural killer cells; it induces apoptosis of neoplastic cells. When ex­pressed in the tumor micro­environment, GB is considered to be a favorable prognostic factor in various types of cancers in humans. A study by Costa, et al published in Oral Oncol­ogy evaluated the density of GB cells in 55 pa­tients with oral cavity squamous cell carcinoma (OC­SCC) and me­tastatic and nonmetastatic lymph nodes utilizing immunohistochemis­­try. The high density of GB cells demonstrated an association with the high percentage of Bax and annexin V neoplastic cells. Further, the number of peritumoral GB cells was significantly higher in the OCSCC group without lymph node metastasis, when compared with the metastatic OCSCC group. OCSCC pa­tients with a high density of peritumoral GB cells demonstrated a longer survival time when compared with pa­tients with a lower density of these cells. In lymph node tissues, the density of GB cells was significantly higher in nonmetastatic lymph nodes than in me­tastatic lymph nodes. The au­thors suggest that the in­creased expression of GB in the tumor microenvironment of OCSCC and in lymph nodes may have a beneficial effect against neoplastic cells, contributing to apoptosis of these cells and in­creased survival of patients.

Source: Oral Oncology, published online January 11, 2010, via elsevier.com)


Dentistry Today is The Nations Leading Clinical News Magazine for Dentists. Here you can get the latest dental news from the whole world quickly.

 

Sponsor Logos